rs11922372 - GMNC - OSTN

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 25903422

  ABSTRACT: Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We identify four novel associations at LOC144817, COG6, RUNX1 and TP63, as well as three novel secondary associations within IFIH1 and IL12B. Fine-mapping analysis of MHC region demonstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of HLA associations between Caucasian and Chinese populations. Further, trans-ethnic comparison suggests population-specific effect or allelic heterogeneity for 11 loci. These population-specific effects contribute s

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