Expressive

rs11918734 - TMEM41A-DT - SENP2

Magnitude 2.2 · 1 study on file

Reported associations

  • Urate, Blood Pressure, and Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 33356394

    ABSTRACT: Supplemental Digital Content is available in the text. Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whether it is exerting a causal effect. To investigate this, we performed Mendelian randomization analysis using data from UK Biobank, Million Veterans Program and genome-wide association study consortia, and meta-analysis of randomized controlled trials. The main Mendelian randomization analyses showed that every 1-SD increase in genetically predicted serum urate was associated with an increased risk of coronary heart disease (odds ratio, 1.19 [95% CI, 1.10-1.30]; P=4×10−5), peripheral artery disease (1.12 [95% CI, 1.03-1.21]; P=9×10−3), and stroke (1.11 [95% CI, 1.05-1.18]; P=2×10−4). In Mendelian randomization med

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • serum urate level Moderate

    rs11918734-T allele associated with higher serum urate levels in large GWAS; urate elevation increases gout and kidney stone risk

    Annual measurement; consult if level > 6.8 mg/dL

Diet

  • excessive alcohol consumption Moderate

    Alcohol reduces renal urate excretion and increases hepatic urate production

    Limit to 2 standard drinks daily for men, 1 for women; beer most problematic

  • high-fructose foods and beverages Moderate

    Fructose metabolism increases endogenous urate production, raising serum urate

    Limit sugar-sweetened beverages and dried fruits

  • high-purine foods Moderate

    Dietary purines are metabolized to urate; reducing intake lowers serum urate levels

    Limit red meat, organ meat, anchovies, sardines to 2-3 servings weekly

Lifestyle

  • adequate daily hydration Moderate

    Higher fluid intake increases urine output and uric acid excretion, reducing serum urate

    Target 2-3 liters water daily; adjust for climate and activity

Screening

  • gout and kidney stone risk assessment Moderate

    Genetically elevated urate increases risk for gout and kidney stone formation

    Discuss with physician if history of joint pain or kidney stones