rs11913634 - TAFA5

Magnitude 2.0 · 1 study on file

Reported associations

• Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders - Unknown journal (n.d.) · Unknown authors · PubMed 37250466

  ABSTRACT: Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci for published summary statistics of problematic alcohol use, problematic tobacco use, cannabis use disorder, and opioid use disorder in a sample of 1,025,550 individuals of European descent and 92,630 individuals of African descent. Nineteen independent SNPs were genome-wide significant (P < 5e-8) for the general addiction risk factor (addiction-rf), which showed high polygenicity. Across ancestries, PDE4B was significant (among other genes), suggesting dopamine regulation as a cross-substance vulnerability. An addiction-rf polygenic risk

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