rs11912828 - PNPLA3
Magnitude 2.2 · 1 study on file
Reported associations
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A genetic map of human metabolism across the allele frequency spectrum - Unknown journal (n.d.) · Unknown authors · PubMed 41044249
ABSTRACT: Genetic studies of human metabolism have been limited in scale and allelic breadth. Here we provide a data-driven map of the genetic regulation of circulating small molecules and lipoprotein characteristics (249 traits) measured using proton nuclear magnetic resonance spectroscopy across the allele frequency spectrum in ~450,000 individuals. Trans-ancestral meta-analyses identify 29,824 locus-metabolite associations mapping to 753 regions with effects largely consistent between men and women and large ancestral groups represented in UK Biobank. We observe and classify extreme genetic pleiotropy, identify regulators of lipid metabolism, and assign effector genes at >100 loci through rare-to-common allelic series. We propose roles for genes less established in metabolic control (
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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omega-3 and omega-6 levels in blood Moderate
PNPLA3 rs11912828 variant significantly affects plasma DHA and omega-6 to omega-3 ratio; monitoring assesses intervention effectiveness
Annual lipid panel including omega-3 and omega-6 levels
Diet
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omega-3 fatty acids from fish and plant sources Moderate
rs11912828 A allele associated with reduced plasma DHA; increased omega-3 intake may help normalize lipid levels
2-3 servings fatty fish weekly or 250-500 mg DHA+EPA supplement daily