rs11912167 - PIWIL3

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide study of genetic polymorphisms predictive for outcome from first-line oxaliplatin-based chemotherapy in colorectal cancer patients - Unknown journal (n.d.) · Unknown authors · PubMed 37539667

  ABSTRACT: We conducted the first large genome-wide association study to identify novel genetic variants that predict better (or poorer) prognosis in colorectal cancer patients receiving standard first-line oxaliplatin-based chemotherapy versus chemotherapy without oxaliplatin. We used data from two phase III trials, NCCTG N0147 and NCCTG N9741and a population-based patient cohort, DACHS. Multivariable Cox proportional hazards models were employed, including an interaction term between each SNP and type of treatment for overall survival (OS) and progression-free survival. The analysis was performed for studies individually, and the results were combined using fixed-effect meta-analyses separately for resected stage III colon cancer (3,098 patients from NCCTG N0147 and 549 patients from DACH

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