rs11903721 - IKZF2
Magnitude 2.2 · 1 study on file
Reported associations
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Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases - Unknown journal (n.d.) · Unknown authors · PubMed 41644669
ABSTRACT: Thyroid diseases are common and highly heritable. We performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: thyroid cancer (ThC), benign nodular goiter, Graves' disease, lymphocytic thyroiditis and primary hypothyroidism. We analyzed genetic association data from ~2.9 million genomes and identified 313 known and 570 new independent loci linked to thyroid diseases. We discovered genetic correlations between ThC, benign nodular goiter and autoimmune thyroid diseases (rg = 0.16-0.97). Telomere maintenance genes contributed to benign and malignant thyroid nodular disease risk, whereas cell cycle, DNA repair and damage response genes were associated with ThC. We propose a paradigm that explains genetic predisposition to benign
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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hypothyroidism genetic risk and screening strategy Moderate
Genetic risk assessment enables personalized preventive screening intervals and symptom awareness
Review rs11903721 genotype with healthcare provider to establish appropriate TSH screening frequency
Screening
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thyroid stimulating hormone (TSH) Moderate
IKZF2 rs11903721 C-allele is associated with elevated hypothyroidism risk; TSH screening detects subclinical and overt hypothyroidism
Obtain baseline TSH; discuss screening interval with healthcare provider based on risk and symptoms