rs11893746 - SLC8A1
Magnitude 2.2 · 1 study on file
Reported associations
-
High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
SLC8A1 rs11893746 genetic blood pressure risk Moderate
rs11893746 in SLC8A1 is significantly associated with increased systolic blood pressure; SLC8A1 encodes sodium-calcium exchanger crucial for cardiac and vascular function.
Discuss this genetic finding with healthcare provider to assess need for enhanced BP monitoring or early intervention
Screening
-
blood pressure monitoring and cardiovascular screening Moderate
Genetic variant associated with elevated baseline systolic blood pressure; regular monitoring aids early detection and prevention of cardiovascular disease.
Check blood pressure regularly; consider additional cardiovascular screening if family history of hypertension