rs11892966 - ABCB11

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic study of intrahepatic cholestasis of pregnancy in Chinese women unveils East Asian etiology linked to historic HBV epidemic. - Journal of hepatology (2025) · Liu Y, Wei Y, Chen X, Huang S, Gu Y, Yang Z, Guo X, Zheng H, Feng H, Huang M, Chen S, Xiao T, Hu L, Zhang Q, Zhang Y, Chen GB, Qiu X, Wei F, Zhen J, Liu S · PubMed 39547589

  Intrahepatic cholestasis of pregnancy (ICP) is the most common and high-risk liver disorder during pregnancy, with varying prevalence across populations. Our understanding of the mechanisms underlying ICP and population-level differences remains limited. This study delves into the genetic etiology of ICP in East Asians, drawing comparisons with Europeans to comprehend ICP etiology in the context of genetic background and evolution. We conducted the hitherto largest-scale genome-wide association study on fasting total serum bile acids (TBA) and ICP in 98,269 Chinese pregnancies. The findings were replicated in three cohorts and compared with European populations. Additionally, phenome-wide association and spatio-temporal evolution analyses were employed to investigate the function and evolu

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