rs11890390 - ACYP2

Magnitude 2.2 · 1 study on file

Reported associations

• Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies - Unknown journal (n.d.) · Unknown authors · PubMed 31171785

  ABSTRACT: Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P < 5 × 10−8). Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with potential roles in telomere biology and DNA repair mechanisms. Meta-analyses with additional 37,505 European individuals reveals six more genome-wide loci, including associations at MPHOSPH6, NKX2-3 and TYMS. We demonstrate that longer LTL associates with protection against respiratory disease mortality [HR = 0.854(0.804-0.906), P = 1.88 × 10−7] in the Singaporean Chinese samples. We further show that the LTL reducing SN

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.