rs11889862 - LINC01931, MMADHC-DT

Magnitude 2.2 · 1 study on file

Reported associations

• Loci at chromosomes 13, 19 and 20 influence age at natural menopause - Unknown journal (n.d.) · Unknown authors · PubMed 19448619

  ABSTRACT: We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; −0.4 year per T allele (39%); P = 6.3 × 10−11), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10−11) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10−8). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease. FULL TEXT: [INTRO] Menopause, the time of a woman's life when menstrual cycle ceases owing to depletion of the follicle pool, is a key event in reproductive aging. It influences a woman's well-being and is an im

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