rs11884776 - ALMS1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links - Unknown journal (n.d.) · Unknown authors · PubMed 24586186

  ABSTRACT: Metabolic traits are molecular phenotypes that can drive clinical phenotypes and may predict disease progression. Here, we report results from a metabolome- and genome-wide association study on 1H-NMR urine metabolic profiles. The study was conducted within an untargeted approach, employing a novel method for compound identification. From our discovery cohort of 835 Caucasian individuals who participated in the CoLaus study, we identified 139 suggestively significant (P<5×10−8) and independent associations between single nucleotide polymorphisms (SNP) and metabolome features. Fifty-six of these associations replicated in the TasteSensomics cohort, comprising 601 individuals from São Paulo of vastly diverse ethnic background. They correspond to eleven gene-metabolite associati

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