rs11884740 - MFF-DT, COL4A3

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-Wide Association Study of Brain Alzheimer's Disease-Related Metabolic Decline as Measured by [18F] FDG-PET Imaging. - Journal of Alzheimer's disease : JAD (2021) · Wang RZ, Yang YX, Li HQ, Shen XN, Chen SD, Dong Q, Wang Y, Yu JT · PubMed 32804141

  Hypometabolism detected by fluorodeoxyglucose F18 positron emission tomography ([18F] FDG PET) is an early neuropathologic changes in Alzheimer's disease (AD) and provides important pathologic staging information. This study aimed to discover genetic interactions that regulate longitudinal glucose metabolic decline in AD-related brain regions. A total of 586 non-Hispanic white individuals from the Alzheimer's Disease Neuroimaging Initiative (ADNI) 1/GO/2 cohorts that met all quality control criteria were included in this study. Genome-wide association study of glucose metabolic decline in regions of interest (ROIs) was performed with linear regression under the additive genetic model. We identified two novel variants that had a strong association with longitudinal metabolic decline in diff

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