rs11881766 - ZNF536
Magnitude 2.2 · 1 study on file
Reported associations
-
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172
ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
cardiovascular screening and central adiposity prevention Moderate
Central adiposity is an independent cardiovascular risk factor; rs11881766 carriers may benefit from early risk assessment and preventive counseling
discuss need for lipid panel, glucose screening, and lifestyle interventions to manage central adiposity
Screening
-
waist circumference and central adiposity Moderate
rs11881766 is associated with increased waist circumference independent of BMI, a marker of central adiposity and metabolic risk
annual measurement; assess trend and maintain under 35 inches (women) or under 40 inches (men)