rs11880910 - PLIN3

Magnitude 2.2 · 1 study on file

Reported associations

• Novel Genetic Locus of Visceral Fat and Systemic Inflammation. - The Journal of clinical endocrinology and metabolism (2020) · Shin J, Syme C, Wang D, Richer L, Pike GB, Gaudet D, Paus T, Pausova Z · PubMed 30942860

  Visceral fat (VF), more than fat elsewhere in the body [mostly subcutaneous fat (SF)], promotes systemic inflammation and related disease. The mechanisms of preferentially visceral accumulation of body fat are largely unknown. To identify genetic loci and mechanistic pathways of preferential accumulation of VF and associated low-grade systemic inflammation. Genome-wide association study (GWAS). Population-based cohort of 1586 adolescents (aged 12 to 19 years) and adults (aged 36 to 65 years). Abdominal VF and SF were measured with MRI, total body fat (TBF) was assessed with bioimpedance, and low-grade systemic inflammation was examined by serum C-reactive protein (CRP) measurement. This GWAS of preferential accumulation of VF identified a significant locus on chromosome 6 at rs803522 (P =

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