Expressive

rs11879596 - PRKCSH, ODAD3

Magnitude 2.2 · 1 study on file

Reported associations

  • Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608

    ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Dietary sodium reduction for blood pressure management Moderate

    Lower sodium intake reduces blood pressure; individuals with genetic hypertension predisposition benefit from sodium restriction.

    Target less than 2300 mg sodium daily

Discuss with your doctor

  • Genetic association with systolic hypertension predisposition Moderate

    Proactive discussion enables personalized cardiovascular risk assessment and preventive strategies aligned with genetic predisposition.

Exercise

  • Regular aerobic exercise for blood pressure management Moderate

    Aerobic activity reduces blood pressure; individuals with genetic predisposition benefit from consistent cardiovascular conditioning.

    150 minutes moderate-intensity aerobic exercise per week

Screening

  • Systolic blood pressure baseline and periodic monitoring Moderate

    rs11879596 A allele is significantly associated with elevated systolic blood pressure in large population studies.

    Establish baseline blood pressure; recheck annually or per clinical guidelines