rs1187362 - NTRK2

Magnitude 2.2 · 1 study on file

Reported associations

• Causality of abdominal obesity on cognition: a trans-ethnic Mendelian randomization study. - International journal of obesity (2005) (2022) · Wang SH, Su MH, Chen CY, Lin YF, Feng YA, Hsiao PC, Pan YJ, Wu CS · PubMed 35538205

  Obesity has been associated with cognition in observational studies; however, whether its effect is confounding or a reverse causality remains inconclusive. This study aimed to investigate the causal relationships of overall obesity, measured by body mass index (BMI), and abdominal adiposity, measured by waist-hip ratio adjusted for BMI (WHRadjBMI), and cognition across European and Asian populations using Mendelian randomization (MR) analysis. We used publicly available genome-wide association study (GWAS) summary data of European ancestry, including BMI (n = 322,154) and WHRadjBMI (n = 210,088) from the GIANT consortium, and cognition performance (n = 257,828) from the UK Biobank and COGENT consortium. Data for individuals of Asian ancestry were retrieved from Taiwan Biobank

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