rs11871801 - CAVIN1

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-Analysis Increases to 71 the Tally of Confirmed Crohn's Disease Susceptibility Loci - Unknown journal (n.d.) · Unknown authors · PubMed 21102463

  [INTRO] We undertook a meta-analysis of six Crohn's disease (CD) genome-wide association studies (GWAS) comprising 6,333 cases and 15,056 controls, and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent/offspring trios. Thirty new susceptibility loci meeting genome-wide significance (P-value <5×10−8) were identified. A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3a, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, the results described here identify a total of 71 distinct loci with genome-wide significant evidence for association with Crohn's disease. [INTRO

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