Expressive

rs11870735 - VPS53

Magnitude 2.2 · 2 studies on file

Reported associations

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

  • The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591

    ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • HDL cholesterol level High

    rs11870735 associates with HDL cholesterol levels in large epidemiologic cohort

    Lipid panel every 3-5 years, target HDL >40 mg/dL (men) or >50 mg/dL (women)

Diet

  • Increase dietary fiber intake Moderate

    Soluble fiber improves glucose control and HDL cholesterol levels

    Consume 25-30g fiber daily from whole grains, legumes, fruits, vegetables

Discuss with your doctor

  • Diabetes prevention strategies Moderate

    rs11870735-C carriers have increased diabetes risk and may benefit from evidence-based prevention approaches

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise improves insulin sensitivity and raises HDL cholesterol

    150 minutes moderate-intensity aerobic activity per week

Screening

  • Type 2 diabetes screening High

    rs11870735-C allele associates with increased type 2 diabetes risk (effect 0.031-0.034 per allele)

    HbA1c or fasting glucose every 3 years if no diabetes diagnosis