rs11870446 - NLRP1 - WSCD1

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1 - Unknown journal (n.d.) · Unknown authors · PubMed 30557369

  ABSTRACT: Genome-wide association studies (GWAS) have identified greater than 30 variants associated with ovarian cancer, but most of these variants were investigated in European populations. Here, we integrated GWAS and subsequent functional analyses to identify the genetic variants with potential regulatory effects. We conducted GWAS for ovarian cancer using 681 Japanese cases and 17,492 controls and found that rs137672 on 22q13.1 exhibited a strong association with a P-value of 1.05 × 10−7 and an odds ratio of 0.573 with a 95% confidence interval of 0.466-0.703. In addition, three previously reported SNPs, i.e., rs10088218, rs9870207 and rs1400482, were validated in the Japanese population (P < 0.05) with the same risk allele as noted in previous studies. Functional studies includi

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