rs1186768 - LINC02183
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways - Unknown journal (n.d.) · Unknown authors · PubMed 36050321
ABSTRACT: The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for ce
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Serum electrolytes - potassium, magnesium, calcium Moderate
Electrolyte deficiencies exacerbate QT prolongation and increase arrhythmia risk
Maintain adequate intake of potassium, magnesium, calcium
Discuss with your doctor
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QT interval findings and cardiovascular implications Moderate
Genetic association with QT prolongation warrants clinical interpretation of baseline ECG findings
Review ECG results with physician or cardiologist
Screening
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ECG screening for baseline QT interval Moderate
The A allele at rs1186768 is associated with increased QT interval, which can increase arrhythmia risk
Obtain 12-lead ECG to establish baseline QTc interval