Expressive

rs11867566 - NACA2 - BRIP1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-Wide Association Studies of Multiple Keratinocyte Cancers - Unknown journal (n.d.) · Unknown authors · PubMed 28081215

    ABSTRACT: There is strong evidence for a role of environmental risk factors involved in susceptibility to develop multiple keratinocyte cancers (mKCs), but whether genes are also involved in mKCs susceptibility has not been thoroughly investigated. We investigated whether single nucleotide polymorphisms (SNPs) are associated with susceptibility for mKCs. A genome-wide association study (GWAS) of 1,666 cases with mKCs and 1,950 cases with single KC (sKCs; controls) from Harvard cohorts (the Nurses' Health Study [NHS], NHS II, and the Health Professionals Follow-Up Study) and the Framingham Heart Study was carried-out using over 8 million SNPs (stage-1). We sought to replicate the most significant statistical associations (p-value≤ 5.5x10-6) in an independent cohort of 574 mKCs and 872 sKC

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Keratinocyte cancer genetic risk and screening plan Moderate

    rs11867566 A allele increases keratinocyte cancer risk; personalized prevention strategy should be established

    Schedule dermatology consultation to discuss screening frequency and sun-protection measures

Lifestyle

  • Prolonged sun exposure without protection Moderate

    UV radiation causes DNA damage; BRIP1 impairment from rs11867566 reduces DNA repair capacity

    Use broad-spectrum SPF 30+ daily; limit midday sun; wear protective clothing and hat

Screening

  • Dermatological screening for skin cancer Moderate

    rs11867566 A allele increases keratinocyte cancer susceptibility through altered BRIP1-mediated DNA repair

    Annual full-body skin exam; more frequent if personal or family skin cancer history

  • Monthly skin self-examination for changing moles Moderate

    Early detection improves keratinocyte cancer outcomes; heightened vigilance warranted given genetic risk

    Check all skin monthly for new or changing lesions using ABCDE method