rs11866404 - SLC6A2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth - Unknown journal (n.d.) · Unknown authors · PubMed 37798380

  ABSTRACT: A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicat

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