rs11864806 - ZNF646, PRSS53
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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dermatophytosis genetic risk and prevention Moderate
Genetic analysis identifies rs11864806 as significantly associated with fungal infection susceptibility
review prevention strategies, hygiene practices, and signs requiring medical evaluation
Screening
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annual dermatological assessment for fungal signs Moderate
rs11864806 G allele associated with significantly elevated dermatophytosis/dermatomycosis risk (GWAS p=1e-36, n=564,982)
annual examination by dermatologist; evaluate any suspicious skin or nail changes