rs1186380 - RPL12P33 - HNF1A-AS1
Magnitude 2.2 · 2 studies on file
Reported associations
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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids - Unknown journal (n.d.) · Unknown authors · PubMed 30926973
ABSTRACT: The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. Editorial summary: A multi-ancestry genome-wide gene-smoking interaction study
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Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304
ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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C-reactive protein (CRP) Moderate
This SNP is associated with elevated C-reactive protein levels, a marker of systemic inflammation and cardiovascular risk.
CRP screening as part of cardiovascular risk assessment; periodic monitoring if elevated
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lipid panel (LDL cholesterol) Moderate
This SNP is associated with higher LDL cholesterol levels in large GWAS studies, indicating increased cardiovascular risk.
Baseline lipid panel if not recently checked; annual monitoring or more frequently if abnormal
Diet
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LDL-lowering dietary modification Moderate
Genetic predisposition to higher LDL cholesterol suggests dietary intervention targeting LDL reduction may be beneficial.
Reduce saturated fat intake; increase soluble fiber, whole grains, plant sterols, and omega-3 fatty acids