Expressive

rs11862987 - SYCE1L - VN2R10P

Magnitude 4.5 · 1 study on file

Reported associations

  • Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia - Unknown journal (n.d.) · Unknown authors · PubMed 33632238

    ABSTRACT: Background Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic risk of CVDs specific to individuals with metabolic diseases. This study aimed to identify disease-specific and/or common genetic loci associated with CVD susceptibility in chronic metabolic disease patients. Methods We conducted a genome-wide association study (GWAS) of a multiple case-control design with data from the City Cohort within Health EXAminees subcohort of the Korean Genome and Epidemiology Study (KoGES_HEXA). KoGES_HEXA is a population-based prospective cohort of 173,357 urban Korean adults that had health examinations at medical centers. 42,393 pa

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • heart-healthy diet emphasizing lipid management Moderate

    Dietary modifications reduce both lipid levels and stroke risk; relevant given dyslipidemia association

    DASH or Mediterranean diet pattern; limit saturated fat and refined carbohydrates

Discuss with your doctor

  • individualized stroke prevention strategy Moderate

    Increased ischemic stroke risk warrants evaluation for preventive therapies and risk factor management

Exercise

  • regular cardiovascular exercise Moderate

    Aerobic exercise reduces ischemic stroke risk; variant carriers benefit from preventive optimization

    150 minutes moderate-intensity aerobic activity per week

Screening

  • blood pressure monitoring Moderate

    Hypertension is major modifiable risk factor for ischemic stroke; variant carriers have elevated baseline risk

    Regular BP checks, target <130/80 mm Hg; discuss with doctor if consistently elevated

  • lipid panel and cardiovascular risk screening Moderate

    Variant associates with ischemic stroke specifically in dyslipidemia context, indicating need for lipid surveillance

    Annual lipid panel, or as recommended by cardiologist based on baseline values