rs11860919 - RN7SKP142 - LINC01571
Magnitude 2.2 · 1 study on file
Reported associations
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Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304
ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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C-reactive protein (CRP) test Moderate
This SNP is strongly associated with elevated CRP; baseline testing confirms status and guides inflammation management strategy.
Baseline CRP test; repeat annually if elevated, every 2-3 years if normal.
Diet
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anti-inflammatory diet Moderate
Higher CRP from this SNP indicates inflammation; anti-inflammatory foods including omega-3s and polyphenols reduce CRP levels.
Emphasize fish, olive oil, leafy greens, berries, legumes; limit refined grains and processed foods.
Exercise
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regular aerobic exercise Moderate
Aerobic exercise is among the most effective interventions for reducing C-reactive protein levels independent of weight loss.
150 min per week moderate aerobic exercise or 75 min vigorous intensity.
Lifestyle
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stress management practice Moderate
Chronic psychological stress elevates C-reactive protein; structured stress management reduces both stress and CRP levels.
Mindfulness, yoga, deep breathing, or similar practice for 20-30 min most days.
Screening
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cardiovascular risk assessment Moderate
C-reactive protein is a validated marker of cardiovascular inflammation and predicts increased risk of heart disease and stroke.
Discuss comprehensive cardiovascular risk assessment given genetic CRP elevation.