Expressive

rs11859077 - VN2R10P - ADAMTS18

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Discuss genetic insomnia predisposition with provider Moderate

    Large GWAS signal warrants clinical assessment for underlying sleep disorder and appropriate management

    Raise sleep difficulties, daytime consequences, and family history of sleep issues

Lifestyle

  • Maintain consistent sleep-wake schedule Moderate

    Regular circadian rhythm supports sleep homeostasis and may reduce expression of genetic predisposition

    Set consistent bedtime and wake time daily, including weekends, within 30-minute window

Screening

  • Screen for insomnia and sleep quality Moderate

    rs11859077 T allele is associated with significantly elevated insomnia risk (GWAS p=9.0e-10, n=2365010)

    Assess sleep onset latency, duration, and daytime impairment at baseline and annually