rs1185902565 - ANKRD36B - UBTFL6

Magnitude 4.5 · 1 study on file

Reported associations

• Rare-Variant Genome-Wide Association and Polygenic Score Assessment of Vitamin D Status in a Middle Eastern Population. - International journal of molecular sciences (2025) · Hendi NN, Umlai UK, Albagha O, Nemer G · PubMed 41096749

  Vitamin D deficiency is highly prevalent in the Middle East despite abundant sunlight; however, most genetic studies have focused on common variants in Europeans only. We analyzed whole-genome sequences from 13,808 Qatar Biobank participants, evaluating rare variants (minor allele frequency 0.01-0.0001) for associations with serum 25-hydroxyvitamin D (25(OH)D) levels and deficiency risk (≤20 ng/mL) in independent discovery ( = 5885) and replication ( = 7767) cohorts, followed by meta-analyses. In quantitative analyses, the discovery cohort identified 41 genome-wide significant signals, including rs192198195 ( = 2.48 × 10 ), and replication found 46, including rs889439631 ( = 2.19 × 10 ), implicating lipid metabolism pathways. In binary analyses, replication revealed rs2605913 ( = 2.8

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.