rs11857866 - FMN1

Magnitude 2.2 · 1 study on file

Reported associations

• Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects - Unknown journal (n.d.) · Unknown authors · PubMed 37612283

  ABSTRACT: Prostate cancer (PrCa) is the second most common cancer worldwide in males. While strongly warranted, the prediction of mortality risk due to PrCa, especially before its development, is challenging. Here, we address this issue by maximizing the statistical power of genetic data with multi-ancestry meta-analysis and focusing on binding sites of the androgen receptor (AR), which has a critical role in PrCa. Taking advantage of large Japanese samples ever, a multi-ancestry meta-analysis comprising more than 300,000 subjects in total identifies 9 unreported loci including ZFHX3, a tumor suppressor gene, and successfully narrows down the statistically finemapped variants compared to European-only studies, and these variants strongly enrich in AR binding sites. A polygenic risk scores

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