Expressive

rs11856927 - CYP19A1, MIR4713HG

Magnitude 2.2 · 1 study on file

Reported associations

  • Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis - Unknown journal (n.d.) · Unknown authors · PubMed 37340002

    ABSTRACT: Integrating genomic data of multiple cancers allows de novo cancer grouping and elucidating the shared genetic basis across cancers. Here, we conduct the pan-cancer and cross-population genome-wide association study (GWAS) meta-analysis and replication studies on 13 cancers including 250,015 East Asians (Biobank Japan) and 377,441 Europeans (UK Biobank). We identify ten cancer risk variants including five pleiotropic associations (e.g., rs2076295 at DSP on 6p24 associated with lung cancer and rs2525548 at TRIM4 on 7q22 nominally associated with six cancers). Quantifying shared heritability among the cancers detects positive genetic correlations between breast and prostate cancer across populations. Common genetic components increase the statistical power, and the large-scale meta

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Excess alcohol consumption Moderate

    Alcohol increases circulating estrogen levels, elevating endometrial cancer risk

    Limit to one or fewer standard drinks daily

Exercise

  • Regular aerobic physical activity Moderate

    Exercise reduces adiposity and circulating estrogen, both reducing endometrial cancer risk

    150 minutes moderate-intensity aerobic activity weekly or equivalent

Lifestyle

  • Maintain healthy body weight Moderate

    Adipose tissue produces estrogen; excess adiposity increases circulating estrogen and endometrial cancer risk

    Target BMI less than 25 through balanced diet and regular movement

Screening

  • Endometrial cancer screening and monitoring plan Moderate

    rs11856927 associated with endometrial cancer risk (p=2e-12, n=185358); CYP19A1 encodes aromatase, regulating estrogen synthesis

    Discuss personalized screening strategy with gynecologist, including baseline imaging if indicated