rs11855441 - GPR176

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease - Unknown journal (n.d.) · Unknown authors · PubMed 30177863

  ABSTRACT: Diverticular disease is common and morbid. Treatments are limited due to poor understanding of its pathophysiology. To elucidate its etiology, we performed a genome-wide association study of diverticular disease (27,444 cases; 382,284 controls) in the UK Biobank and tested for replication in the Michigan Genomics Initiative (2,572 cases; 28,649 controls). We identified 42 loci associated with diverticular disease, 39 of them novel. Using DEPICT, we show that genes in these associated regions are significantly enriched for expression in mesenchymal stem cells and multiple connective tissue cell types and are co-expressed with genes that play a role in vascular and mesenchymal biology. Genes in these associated loci play roles in immunity, extracellular matrix biology, cell adhesio

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