rs11846882 - ESR2, SYNE2

Magnitude 2.2 · 1 study on file

Reported associations

• Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies - Unknown journal (n.d.) · Unknown authors · PubMed 32109663

  ABSTRACT: Backgrounds and aims: Several genes are known to contribute to the levels and metabolism of HDL-C, however, their protective effects in cardiovascular disease (CVD), healthy aging, and longevity are complex and poorly understood. It is also unclear if these genes predict longitudinal HDL-C change. We aimed to identify loci influencing HDL-C change. Methods: We performed a genome-wide association study (GWAS) with harmonized HDL-C and imputed genotype in three family-based studies recruited for exceptional survival (Long Life Family Study), from community-based (Framingham Heart Study) and enriched for CVD (Family Heart Study). In 7738 individuals with at least 2 visits, we employed a growth curve model to estimate the random linear trajectory parameter of age-sex-adjusted HDL-C f

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