Expressive

rs11846409 - IGHV3-62 - IGHVII-62-1

Magnitude 2.0 · 2 studies on file

Reported associations

  • A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations - Unknown journal (n.d.) · Unknown authors · PubMed 37780799

    ABSTRACT: Background Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed. Objective We sought to detect genetic variants associated with differences in immune responsiveness against allergen components. Methods The participants of the present study were recruited from the Tokyo Children's Health, Illness, and Development study, and allergen component-specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen compone

  • Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania - Unknown journal (n.d.) · Unknown authors · PubMed 28492228

    ABSTRACT: The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 399 cases and 617 controls). We identify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsynonymous variants in the IGHV4-61 gene segment corresponding to the IGHV4-6102 allele. We show each copy of IGHV4-6102 is associated with a 1.4

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