Expressive

rs11842326 - RPL13AP25 - LINC02335

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular aerobic exercise Moderate

    Exercise improves sleep consolidation through increased adenosine and enhanced circadian timing.

    150 minutes per week moderate aerobic exercise, completed at least 3 hours before bedtime

Lifestyle

  • Optimize sleep hygiene practices Moderate

    Genetic predisposition to insomnia suggests impaired sleep homeostasis.

    Maintain consistent bedtime and wake time, keep bedroom cool and dark, avoid screens 1 hour before bed

Screening

  • Evaluate sleep quality and insomnia history Moderate

    The rs11842326 A allele is associated with increased insomnia susceptibility in genome-wide studies.

    Discuss sleep patterns, quality, and any insomnia symptoms with healthcare provider