rs11841272 - TNFRSF19

Magnitude 2.2 · 1 study on file

Reported associations

• Joint Association Analysis Identified 18 New Loci for Bone Mineral Density. - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2020) · Pei YF, Liu L, Liu TL, Yang XL, Zhang H, Wei XT, Feng GJ, Hai R, Ran S, Zhang L · PubMed 30690781

  Bone mineral density (BMD) at various skeletal sites have shared genetic determinants. In the present study, aiming to identify shared loci associated with BMD, we conducted a joint association study of a genomewide association study (GWAS) and a meta-analysis of BMD at different skeletal sites: (i) a single GWAS of heel BMD in 142,487 individuals from the UK Biobank, and (ii) a meta-analysis of 30 GWASs of total body (TB) BMD in 66,628 individuals from the Genetic Factors for Osteoporosis (GEFOS) Consortium. The genetic correlation coefficient of the two traits was estimated to be 0.57. We performed joint association analysis with a recently developed statistical method multi-trait analysis of GWAS (MTAG) to account for trait heterogeneity and sample overlap. The joint association analysi

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