rs11836750 - LINC02388
Magnitude 2.2 · 1 study on file
Reported associations
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Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity - Unknown journal (n.d.) · Unknown authors · PubMed 32121467
ABSTRACT: Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we examined the relationship between endometriosis and migraine using genome-wide association study (GWAS) data. Single nucleotide polymorphism (SNP) effect concordance analysis found a significant concordance of SNP risk effects across endometriosis and migraine GWAS. Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation (rG = 0.38, P = 2.30 × 10−25) between endometriosis and migraine. A meta-analysis of endometriosis and migraine GWAS data did not reveal novel genome-wide significant SNPs,
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic association with endometriosis and migraine Moderate
rs11836750 G allele is associated with endometriosis and/or migraine; discussion helps personalize preventive strategies
Share genetic finding with healthcare provider to explore screening and prevention options
Screening
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Endometriosis and migraine symptom monitoring Moderate
rs11836750 G allele associates with increased endometriosis and migraine risk; monitoring enables early detection and management
Seek evaluation if experiencing chronic pelvic pain, heavy/painful periods, or recurrent headaches