rs11835157 - ELK3

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid. - Clinica chimica acta; international journal of clinical chemistry (2015) · Park TJ, Park JS, Cheong HS, Park BL, Kim LH, Heo JS, Kim YK, Kim KU, Uh ST, Lee HS, Na JO, Seo KH, Choi JS, Kim YH, Kim MS, Park CS, Shin HD · PubMed 24792382

  Asthma can be suppressed by inhaled corticosteroids (ICS). However, response to ICS shows marked inter-individual variability. This study is aimed to identify the genetic variants associated with the change in the percentage of forced expiratory volume in 1second (%ΔFEV1) following ICS treatment. A genome-wide association study was performed in a Korean asthmatic cohort. To further investigate these genetic associations, 11 additional single-nucleotide polymorphisms (SNPs) on the allantoicase (ALLC) gene were selected from the HapMap database and genotyped in the same asthmatic patients in the follow-up study. In a genome-wide study, we identified the lowest P-value in ALLC, but none of the SNPs met the genome-wide association criteria (P<1.0×10(-8)). However, among 25 SNPs on ALLC in th

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