rs11830243 - EP400
Magnitude 2.2 · 1 study on file
Reported associations
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Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925
ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Regular aerobic and resistance exercise Moderate
Physical activity improves insulin sensitivity and glucose metabolism, substantially reducing diabetes risk particularly in genetically susceptible individuals
150 minutes weekly moderate-intensity aerobic activity plus resistance training 2-3 times weekly
Screening
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Type 2 diabetes metabolic screening Moderate
rs11830243-C allele is significantly associated with increased type 2 diabetes risk (p=2e-9); baseline assessment enables early detection of glucose dysregulation
Baseline fasting glucose, 2-hour glucose tolerance test, HbA1c; repeat every 1-3 years based on results