rs1182959 - DGKH
Magnitude 2.2 · 1 study on file
Reported associations
-
Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations - Unknown journal (n.d.) · Unknown authors · PubMed 37787550
ABSTRACT: Visual Abstract Significance Statement Kidney stone disease is a common disorder with poorly understood pathophysiology. Observational and genetic studies indicate that adiposity is associated with an increased risk of kidney stone disease. However, the relative contribution of general and central adipose depots and the mechanisms by which effects of adiposity on kidney stone disease are mediated have not been defined. Using conventional and genetic epidemiological techniques, we demonstrate that general and central adiposity are independently associated with kidney stone disease. In addition, one mechanism by which central adiposity increases risk of kidney stone disease is by increasing serum calcium concentration. Therapies targeting adipose depots may affect calcium homeostas
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
personalized kidney stone prevention strategy Moderate
Individual stone composition and metabolic risk factors require medical assessment
Lifestyle
-
increased daily fluid intake for stone prevention Moderate
Adequate hydration reduces urinary concentration of stone-forming crystals
maintain at least 2.5-3 liters daily; adjust to produce >2 liters urine
Screening
-
baseline kidney function assessment Moderate
Early detection enables preventive intervention for stone formation
obtain urinalysis and serum creatinine at baseline; consider 24-hour urine studies