Expressive

rs11828907 - AHNAK

Magnitude 4.5 · 1 study on file

Reported associations

  • Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 28714976

    ABSTRACT: Introduction We identified rare coding variants associated with Alzheimer's disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008),

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean-style dietary pattern Moderate

    Plant-based, olive-oil-rich diet is associated with reduced Alzheimer's disease risk and progression

    Emphasize vegetables, fruits, whole grains, legumes, olive oil, fish; minimize red meat and processed foods

Discuss with your doctor

  • Genetic risk for Alzheimer's disease and prevention strategy Moderate

    AHNAK C allele is associated with significantly elevated late-onset Alzheimer's disease risk (p=2e-7)

    Discuss genetic risk, baseline cognitive status, monitoring plan, and modifiable risk factors with healthcare provider

Exercise

  • Regular aerobic exercise for cognitive health Moderate

    Aerobic activity supports cognitive reserve and reduces dementia risk in genetically susceptible individuals

    150 minutes moderate-intensity aerobic exercise per week, spread across 3 or more days

Lifestyle

  • Cognitive engagement and mental stimulation Moderate

    Cognitive reserve from active learning reduces Alzheimer's disease risk and slows cognitive decline

    Daily intellectual activity - puzzles, learning, reading, social engagement; 30+ minutes daily

Screening

  • Cognitive assessment for dementia detection Moderate

    AHNAK C allele is associated with substantially increased late-onset Alzheimer's disease risk

    Baseline cognitive testing; annual or biennial reassessment starting age 50