rs1182870 - LINC01717 - LINC01774

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - Unknown journal (n.d.) · Unknown authors · PubMed 39436105

  ABSTRACT: ABSTRACT Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if genetic risk contributes to this observed association. We carried out a genome-wide association study (GWAS) analysis in the Michigan Genomics Initiative and the United Kingdom Biobank for CDI based on ICD codes and meta-analyzed these results with similar publicly accessible GWAS summary statistics from Finngen. Conditional and joint multi-SNP analyses were used to identify independent associations. Imputation of the human leukocyte antigen (HLA) region with fine mapping was used to try to identify causal HLA allele groups. Two-sample bidirectional Mendelian randomization (MR) was implemented to determine causal relationships

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