rs1182155 - GNA12
Magnitude 2.2 · 1 study on file
Reported associations
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New role of fat-free mass in cancer risk linked with genetic predisposition - Unknown journal (n.d.) · Unknown authors · PubMed 38538606
ABSTRACT: Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMB
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Adequate protein intake for muscle synthesis Moderate
C allele carriers with higher lean mass potential require sufficient protein substrate for maintenance
1.2-1.6 g/kg body weight daily from varied sources
Exercise
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Regular resistance training for lean muscle Moderate
C allele associated with higher fat free mass; resistance exercise synergizes with genetic predisposition
3-4 sessions weekly targeting major muscle groups
Screening
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Body composition assessment and tracking Moderate
C allele carriers' lean mass predisposition can be objectively tracked via body composition measurement
DEXA scan or bioimpedance analysis annually or every 2 years