Expressive

rs1181906 - SHH - Y_RNA

Magnitude 2.2 · 1 study on file

Reported associations

  • Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants - Unknown journal (n.d.) · Unknown authors · PubMed 28235828

    ABSTRACT: Maternal exposure to environmental pollutants could affect fetal brain development and increase autism spectrum disorder (ASD) risk in conjunction with differential genetic susceptibility. Organohalogen congeners measured in maternal midpregnancy blood samples have recently shown significant, but negative associations with offspring ASD outcome. We report the first large-scale maternal and fetal genetic study of the midpregnancy serum levels of a set of 21 organohalogens in a subset of 790 genotyped women and 764 children collected in California by the Early Markers for Autism (EMA) Project. Levels of PCB (polychlorinated biphenyl) and PBDE (polybrominated diphenyl ether) congeners showed high maternal and fetal estimated SNP-based heritability (h2g) accounting for 39-99% of th

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Foods high in organochlorine pesticide residues Moderate

    rs1181906 is associated with higher circulating organochlorine pesticide levels; genetic predisposition increases accumulation and fetal/infant exposure risk

    Choose organic options for high-residue foods (especially animal products and fatty fish); vary sources

Discuss with your doctor

  • Organochlorine pesticide exposure reduction strategy Moderate

    rs1181906 is associated with higher organochlorine pesticide accumulation; proactive exposure reduction may minimize fetal and infant exposure

    If planning pregnancy, discuss pesticide avoidance strategies with OB/GYN or primary care provider

Screening

  • Organochlorine pesticide serum levels Moderate

    Genetic predisposition increases accumulation; measurement identifies individual exposure burden, particularly during pregnancy when fetal exposure is a concern

    Request serum organochlorine pesticide screening if planning pregnancy or currently pregnant