rs118176061 - OR4A6P - TRIM48
Magnitude 4.5 · 1 study on file
Reported associations
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Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty - Unknown journal (n.d.) · Unknown authors · PubMed 32986727
ABSTRACT: Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We conducted a meta-analysis of GWAS summary statistics from multiple hearing-related traits in the UK Biobank (n = up to 330,759) and identified 31 genome-wide significant risk loci for self-reported hearing difficulty (p < 5x10-8), of which eight have not been reported previously in the peer-reviewed literature. We investigated the regulatory and cell specific expression for these loci by generating mRNA-seq, ATAC-seq, and single-cell RNA-seq from cells in the mouse cochlea. Risk-associated genes were most strongly enriched for expression in cochlear epithelial cells, as well as for genes related to sensory perception and known
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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chronic occupational noise exposure Moderate
Genetic predisposition compounds cochlear damage from noise exposure
Use hearing protection in loud environments, keep occupational noise <85dB
Screening
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baseline audiometry by age 50 Moderate
SNP associated with age-related hearing impairment; early detection enables intervention
Baseline audiometry by age 50, repeat every 3-5 years
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hearing function status Moderate
Genetic risk warrants proactive monitoring for early hearing changes
Annual audiometry after age 60, or sooner if hearing symptoms develop