Expressive

rs118175510 - LINC02702 - BUD13

Magnitude 2.2 · 2 studies on file

Reported associations

  • Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923

    ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa

  • A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907

    ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Triglyceride level monitoring Moderate

    GWAS association indicates genetic predisposition to elevated triglycerides with C allele

    Assess baseline triglycerides; recheck annually or per physician recommendation

Diet

  • Excessive alcohol consumption Moderate

    Alcohol increases hepatic triglyceride production

    Limit to 0-1 drinks daily for women, 0-2 for men

  • Refined carbohydrates and added sugars Moderate

    Simple carbohydrates and fructose increase hepatic triglyceride synthesis

    Limit refined grains, sugary beverages, and processed foods with added sugars

  • Soluble fiber from whole foods Moderate

    Soluble fiber reduces triglyceride levels through multiple metabolic pathways

    10-15 grams daily from oats, beans, legumes, and fruits; increase gradually

Discuss with your doctor

  • Medication for triglyceride management Moderate

    Genetic predisposition to elevated triglycerides may warrant pharmacotherapy if lifestyle insufficient

Exercise

  • Regular aerobic exercise Moderate

    Aerobic activity directly lowers circulating triglyceride levels

    150 minutes per week of moderate-intensity aerobic exercise

Supplements

  • Omega-3 fatty acids (EPA/DHA) Moderate

    Omega-3 polyunsaturated fats reduce triglyceride synthesis and increase clearance

    2-3 grams per day of combined EPA and DHA, or fatty fish 2-3 times weekly