Expressive

rs118163475 - YIPF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • saturated fat and trans fat intake Moderate

    Dietary saturated and trans fats increase LDL cholesterol; T allele increases baseline LDL risk

    Limit saturated fat to <7% of daily calories; eliminate trans fats

  • soluble fiber from whole food sources Moderate

    Soluble fiber reduces LDL cholesterol absorption; T allele increases baseline LDL risk

    Consume 25-30g daily fiber from oats, beans, fruits, vegetables

Discuss with your doctor

  • cardiovascular risk and prevention strategies Moderate

    T allele associated with elevated LDL cholesterol; LDL is major cardiovascular disease risk factor

Exercise

  • aerobic exercise for LDL management Moderate

    Regular aerobic activity raises HDL and can lower LDL and triglycerides; T allele increases LDL risk

    150 minutes moderate-intensity aerobic activity per week

Screening

  • lipid panel with LDL cholesterol measurement Moderate

    T allele of rs118163475 is associated with elevated LDL cholesterol levels in large GWAS study

    Check lipid panel every 1-2 years or as recommended by physician