rs11816044 - IL2RA-AS1, IL2RA

Magnitude 2.2 · 1 study on file

Reported associations

• Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity - Unknown journal (n.d.) · Unknown authors · PubMed 36778051

  ABSTRACT: Summary Asthma is a complex disease that varies widely in prevalence across populations. The extent to which genetic variation contributes to these disparities is unclear, as the genetics underlying asthma have been investigated primarily in populations of European descent. As part of the Global Biobank Meta-analysis Initiative, we conducted a large-scale genome-wide association study of asthma (153,763 cases and 1,647,022 controls) via meta-analysis across 22 biobanks spanning multiple ancestries. We discovered 179 asthma-associated loci, 49 of which were not previously reported. Despite the wide range in asthma prevalence among biobanks, we found largely consistent genetic effects across biobanks and ancestries. The meta-analysis also improved polygenic risk prediction in non-E

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