Expressive

rs11814924 - DENND10

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limit saturated fat and dietary cholesterol Moderate

    rs11814924-A allele associated with elevated cholesterol; dietary modification is standard management for genetic cholesterol risk

    Keep saturated fat below 10% of daily calories; aim for under 200mg dietary cholesterol daily

Discuss with your doctor

  • cholesterol management strategy with physician Moderate

    rs11814924-A allele associated with elevated cholesterol; genetic predisposition warrants professional evaluation and management planning

Exercise

  • regular cardiovascular exercise Moderate

    rs11814924-A allele associated with elevated cholesterol; exercise improves lipid profiles and may mitigate genetic risk

    At least 150 minutes of moderate aerobic activity per week

Screening

  • lipid panel including total and LDL cholesterol Moderate

    rs11814924-A allele increases DENND10 expression and is associated with elevated total and LDL cholesterol, warranting closer monitoring of lipid levels

    Every 1-2 years if normal; annually if elevated