Expressive

rs118122632 - CYP4F35P, CYP4F35P

Magnitude 2.2 · 1 study on file

Reported associations

  • A Genome-Wide Association Study Identifies Two Sex-specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites - Unknown journal (n.d.) · Unknown authors · PubMed 28181694

    ABSTRACT: Failure to achieve optimal bone mineral accretion during childhood and adolescence results in subsequent suboptimal peak bone mass, contributing to osteoporosis risk later in life. To identify novel genetic factors that influence pediatric bone mass at discrete skeletal sites, we performed a sex-stratified genome-wide association study of areal bone mineral density (BMD) measured by dual energy X-ray absorptiometry at the 1/3 distal radius, spine, total hip and femoral neck in a cohort of 933 healthy European American children. We took forward signals with P<5x10−5 and minor allele frequency (MAF) >5% into an independent cohort of 486 European American children in search of replication. In doing so, we identified five loci that achieved genome wide significance in the combined

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate dietary calcium intake Moderate

    rs118122632-C is associated with lower pediatric bone mineral density; sufficient dietary calcium is essential for bone mineralization

    1000-1300 mg/day for children and adolescents

Exercise

  • weight-bearing and resistance exercise Moderate

    physical activity stimulates bone formation and mineralization; particularly important for rs118122632-C carriers at risk of suboptimal bone density

    30-60 minutes most days per week of weight-bearing or resistance activities

Screening

  • bone density assessment with provider Moderate

    rs118122632-C carriers show significantly lower pediatric bone mineral density; baseline assessment may guide preventive interventions

Supplements

  • vitamin D supplementation Moderate

    vitamin D is critical for calcium absorption and bone formation; carriers of rs118122632-C allele show lower bone mineral density and may benefit from optimization

    400-1000 IU/day (children/adolescents), dose adjusted to target 25-OH-D 30-50 ng/mL