Expressive

rs118121724 - OGFOD1, BBS2

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic insomnia risk and clinical screening Moderate

    BBS2/OGFOD1 rs118121724-T allele associates with insomnia in large GWAS (n=1.4-2.4M, p<1e-8); warrants clinical assessment

Lifestyle

  • Sleep quality and insomnia patterns Moderate

    rs118121724-T allele is strongly associated with insomnia across multiple large GWAS cohorts; tracking sleep enables early detection

    Log sleep duration and quality daily; document frequency and severity of sleep disruptions

  • Structured sleep hygiene optimization Moderate

    Genetic predisposition to insomnia may be mitigated through consistent sleep environment and behavioral modifications

    Establish consistent sleep/wake times; maintain cool, dark, quiet bedroom; avoid screens 1 hour before bed